A New York Times nonfiction bestseller, which is not necessarily an indicator of quality.

I read this book because while looking up something else entirely, I came across a review mentioning that it concludes with a very raw and honest account of the author's mental health issues. I'm not much interested in longevity, but I'm very interested in raw and honest accounts of mental health issues. I checked out a copy intending to only read the last chapter, but after I read that (which is as described) I got curious, went back to the beginning, and read the whole thing.

Attia is a doctor with a podcast. Outlive has some interesting/useful material, but also a distinct whiff of wealthy techbro who hangs out and creates startups with other wealthy techbros. Attia mentions a friend of his in a way that made me feel certain that the friend was a deeply obnoxious wealthy techbro, so I looked up the friend and discovered that he wrote this book:



Thousands of tests later, this book contains the answers for both men and women. It’s the wisdom Tim used to gain 34 pounds of muscle in 28 days, without steroids, and in four hours of total gym time.

• How to sleep 2 hours per day and feel fully rested
• How to produce 15-minute female orgasms
• How to triple testosterone and double sperm count


How much would you guys pay me to read and review the "turn into a testosterone-fueled orgasmatron muscleman in 4 hours" book?)

Here is a short summary of Outlive: Most doctors do Medicine 2.0, which is focused on treatment. Attia advocates Medicine 3.0, which is focused on prevention. He's interested in staying healthy and happy into old age, not in old age regardless of health and happiness. If you can avoid infectious diseases and violence/accidents, most morbidity and mortality nowadays is caused by four categories of diseases: cancer, heart disease/stroke, neurodegenerative disease (like dementia), and Type 2 diabetes/metabolic issues. Mortality and morbidity from those is often preventable or delayable, though more for heart disease and diabetes than the other two.

The first part of the book is a deep dive into those four conditions and their causes. While I and probably you know the general overview, he also drops a bunch of little bits of information that I was not already aware of, and when I looked up the new bits, I found that while he has his opinions, he was not just making them up. (Just making up stuff is a significant problem in health literature.) He's not a weight loss evangelist, and he admits that there's a lot of genetic and random/unknown factors involved in these diseases, so the book came across as a bit less victim-blaming than these sorts of books usually do.

The second part of the book is his advice on how to prevent/delay those diseases, and how to live to an old age while staying healthy. Imagine whacking a pinata and having advice spray out in a mix of good, possibly good, a good idea in theory but impossible unless you are his personal patient and very wealthy and have unlimited time on your hands and no disabilities or chronic illnesses, probably batshit, and so vague as to be completely useless. So that was a wild ride.

His section on diet has some good points (different people have different dietary needs) but others that are dubious (we should cut calories but also eat WAY more protein) and his method for figuring out what your personal dietary needs are is impossible for most people (experiment with your diet and use extensive blood tests, continuous glucose monitoring, DEXA scans, and other fancy stuff to see how you react). I appreciated that he was honest about how little we really know about the relationship of diet to health, and how complex it is. He says he used to be really sold on various types of fasting but has now decided that it's mostly not worth it as you lose too much muscle mass. He's agnostic on keto.

What he's most sold on is exercise. I liked this aspect of the book, as I enjoy exercise so it was pleasing to have him tell me that regardless of my crummy genes and fondness for fresh-baked bread, I might live to a very healthy old age by doing activities I enjoy anyway. He had some specific tips on types of exercise that I will probably try out at some point. (TOE YOGA.) Finally, he suggested figuring out what physical activities you want to be able to do when you're in your 80s, and focus on maintaining the skills and strength you need for those specifically. This seems very reasonable.

However, he could not resist a long foray into "a good idea in theory but impossible for most people," which was that since aging causes a loss of physical capacity in fairly predictable ways, if you want to be strong in old age, you need to get exceptionally strong now. If you want to lift 40lbs when you're eighty and you statistically lose 50% of lifting capacity by then, you can't just work on lifting 40 lbs now, you need to work up to lifting 80lbs now.

He goes on to advocate preventing age-related decline by aiming to hit the top 10% of the capability of people 20 years younger than you, so as you age you'll be declining from a much higher point. This is a brilliant idea if you're independently wealthy, have lots of time on your hands, and also have outstanding athletic potential. Otherwise, not very practical. To say the least.

He really underestimates the issue of unpredictable injuries or illnesses. He says you can avoid training injuries by learning "stability," which is tautologically defined as the ability to exercise without injuring yourself. This is good in theory but even if you could get the training he suggests which is only via a specific and no doubt wildly expensive personal trainer, no type or amount of training is a certain preventative for injuries. To say the least. And that's not even getting into the very common wild card factor of illnesses that can affect your physical fitness.

The last chapter was about how he realized that he was a ragey asshole, was forced to address his childhood trauma, and how he uses DBT to manage his issues. It was indeed raw and honest though WOW do I feel sorry for his wife. He makes very good points on how it's pointless to be focus on physical health if you're ignoring your horrible mental health. But it also had the "impossible for most people" issue in that he did several stints of month-long voluntary inpatient treatment at a fancy private facility and has three private therapists who are all famous in their own right.

Reading the entire book, you get a real sense of him as a person: obsessive, intense, perfectionist, prone to flinging himself into a concept like keto or fasting and then abandoning it with equal fervor. DBT does seem like a good choice for him.

He's probably a good doctor for his patients, because the only people who can afford his $90,000/year fees and would find them worthwhile are the sort of people who can and would follow his advice. But the guy has absolutely no idea what it's like to not have unlimited money, time, and energy to devote to your health. Some of what he advises would be a more practical in countries other than America, but a lot of it is wildly impractical anywhere. Most people are not capable of reaching the top 10% of athleticism of people 20 years younger than them!

I'm fascinated that this is such a big bestseller, because there's such a tiny fraction of the population that could follow his regime. As far as I can tell, his ideal audience is very rich, very athletic techbros who are obsessively dedicated to hacking their health. It's a real population which includes the author, but in a global sense a very small one.

My favorite part of the book is when he tells the story of rapamycin, which I hadn't heard of before and it's WILD. It's used for various purposes, most commonly to prevent organ rejection, but may increase longevity. Attia confesses that he prescribes it off-label to himself and a few of his patients for that purpose. Good luck, medbro! Hope it doesn't give you any of the very long and scary list of side effects noted in its black box warning!

ETA: Forgot to mention that doing 30 minutes of a dry sauna four days a week reduces mortality by 65%. Being immortal is a full-time job.

The book takes place over three hours in an ER in the ominously named The City, with chapters broken up among many points of view and labeled with their exact time. It's going for an Arthur Hailey/James Michener-esque epic in a very short space, and it does succeed in capturing that type of feel.

The characters we follow include a college student who's hit by a stray bullet in a gang shootout, a gangster who shows up at the ER to finish off the guy he shot on purpose, and a high school student who crashes a motorcycle. The characters I cared the most about are interestingly both there not for medical reasons but to escape their homes: a teenage mother of twins at the end of her rope, and an eight-year-old neglected child there who brought her younger siblings with her because there's air conditioning and crayons.

The main characters are a pair of aspiring medical students volunteering at the ER, Seth and Diana. Seth is humorless and arrogant. Diana is insecure and sharp-tongued. The book had other problems but they were one of the biggest. I neither liked nor cared about either of them.

The book was written in 1997 and you can tell, in good, bad, and historically interesting ways. An HIV positive baby is going to die, period. The City is a complete urban hellscape where it's dangerous to go outside because you WILL get shot... which is actually true of America to some degree, but it's described in a very 1997 way.

Cooney goes well out of her way to not be racist about what is essentially a racist trope, and succeeds to some extent (she has a multiracial cast of all sorts of people) but accidentally shines light on exactly how racist that trope is. I kept being brought up short by her gangsters being white (or at least some of them are, I forget), because they're described in a way that is pretty much always reserved for teenage Black gangsters. Calling it the City was a mistake, IMO; just inventing a city with a name would have worked better. The allegorical name clashes with the realistic details and also adds to the sense of "cities are terrifying hellscapes filled with scary people of color" except Cooney clearly doesn't agree with that part so she kept everything but that, highlighting how completely nonsensical the trope is - it has literally no basis beyond racism.

I was hoping this would be along the lines of Flight #116 is Down! and it kind of is, but it's nowhere near as good. It's not a failure by any means - it wants to tell an exciting and informative story about what a big-city ER is like - but that's all it is. It's a perfectly fine example of what it is, but Flight #116 is Down! is above and beyond what it is.

My internet rabbit hole on pioneering plastic surgeon Archibald McIndoe and the Guinea Pig Club (WWII aviators who were burned and got reconstructive surgery) produced a remarkable amount of !!! from Wikipedia alone. A number of them had distinctly "you can't make this shit up" lives. (There's also one who possibly did make some shit up.)

For your interest, I present some of my favorite bits.

I had a row with a German.

Tom Gleave

"Gleave was shot down on his first sortie after restoration of his command, on 31 August 1940, and badly burned. Initially treated at Orpington Hospital, he regained consciousness underneath a bed during an air raid. His wife was called to his bedside and asked the heavily bandaged Gleave "what on earth have you been doing with yourself?" "I had a row with a German" was his characteristically laconic reply."



If you click through to just one article, make it this one.

Alois Šiška

This guy's story is incredible from beginning to end. Here's ONE section:

"Šiska was a member of an illegal cell through which he helped Jews and others escape to Poland and later to Hungary. He remained in the republic until the outbreak of war. At that time, fear grew that the Germans would discover a hidden prototype of the Z-XIII aircraft. In order not to fall into their hands, it was decided within the illegal group that the prototype must fly to the Balkans. However, this plan failed.

Together with Alois Bača, they fled across the frozen river Morava to Slovakia, then with the help of a Hungarian pastor, they crossed the Slovak-Hungarian border and continued by train to the border with Yugoslavia. There they were arrested by a Hungarian border guard and imprisoned in Hodmezövasárhely prison for several weeks. After a failed escape attempt, they were deported to the Citadella in Budapest.

Here they were held in harsh conditions together with another hundred and twenty Czechs and a similar number of Poles. An opportunity to escape did not come until 30 March 1940, when Šiška reported to the doctor suffering from scabies. He managed to escape his guards and took a taxi to the French consulate."

Now imagine that sequence of getting captured and imprisoned, then escaping repeating several more times, interspersed with a shipwreck, a lengthy life raft survival situation, and only escaping getting his feet amputated because he seemingly dropped dead.

This line in his Wikipedia entry caused me some confusion when I attempted to search for his memoir: Šiška authored the book No Response KX-B.



The OTHER pilot who flew in combat with two prosthetic legs.

Colin Hodgkinson

This guy had both his legs amputated, then returned to being a fighter pilot! There were at least two men who did this during WWII.

"On 24 November 1943, during a high-altitude weather reconnaissance mission from 11.50, in Amiens area his oxygen supply failed 6 m E. of Hardelot, causing him to crash land in a field. He was dragged from his burning Spitfire by two farm workers, losing an artificial leg in the process. For the next 10 months he was held in Stalag Luft III prisoner-of-war camp, before being repatriated and deemed "no further use to his country". He was again treated by McIndoe and he continued to fly until his release from service in 1946."



On the bright side, a shell severed the control lever and the throttle got stuck on open.

Eric Lock

"On 8 November 1940 his Spitfire was badly damaged during a skirmish with several Bf 109s over Beachy Head in East Sussex. The Spitfire was so badly damaged that Lock crash-landed in a ploughed field, but was able to walk away. On 17 November 1940 No. 41 Squadron attacked a formation of 70 Bf 109s that were top cover for a bomber raid on London. After shooting down one Bf 109, and setting another on fire, Lock's Spitfire was hit by a volley of cannon shells, which severely injured Lock's right arm and both legs.

The rounds also knocked the throttle permanently open by severing the control lever. The open throttle enabled the Spitfire to accelerate swiftly to 400 mph, leaving the Bf 109s in his wake, without Lock having to attempt to operate it with his injured right arm.

At 20,000 feet (6,100 m) he began to descend and with little control and no means of slowing the fighter down, he could not execute a safe landing; being too badly injured to parachute to safety, Lock was in a perilous situation. After losing height to 2,000 feet (610 m), Lock switched the engine off and found a suitable crash site near RAF Martlesham Heath, Suffolk, into which he glided the stricken fighter for a "wheels down" landing.

Lying in the aircraft for some two hours, he was found by two patrolling British Army soldiers and carried two miles (3 km) on an improvised stretcher made of their Enfield rifles and Army issue winter coats—made after instruction from Lock. By this point, Lock had lost so much blood that he was unconscious, and so unable to feel the additional pain of being dropped three times, once into a dyke of water."

Like the war wasn't bad enough.

Jackie Mann.

"Jackie Mann, CBE, DFM was a Royal Air Force fighter pilot in the Battle of Britain, who in later life was kidnapped by Islamists in Lebanon in May 1989 and held hostage for more than two years."

A single swipe of a spade.

Richard Pape

"He became a sergeant navigator in a Short Stirling bomber. On a 1941 mission he was shot down close to the German/Dutch border, was twice captured and twice escaped. Following his second capture he was tortured by the Gestapo. He was repatriated by the Germans on health grounds in 1944.

In November of that year he was on a retraining course when he was burnt in a drunken motorcycle accident on the Isle of Man, which led to his being hospitalised at Queen Victoria Hospital, East Grinstead, for pioneer plastic surgery under Archibald McIndoe: he thus became a member of the Guinea Pig Club."

Also, he was mad at the Beatles.

An Amazon review of his book: Time and time again I thought that what I was reading did not have a ring of truth about it, and in some cases the account was simply unbelievable. A good example of the latter is a story of a fight between two prisoners where one cuts off the other's head with a single swipe of a spade.



Wait for the last line.

Mollie Lentaigne was not a member of the club herself, but a nurse and artist on the medical staff.

"Lentaigne worked as a Red Cross Voluntary Aid Detachment nurse at the Queen Victoria Hospital, East Grinstead, West Sussex, where her duties included drawing the experimental operations of Archibald McIndoe and his fellow surgeons. She needed to work quickly in the operating theatre and so used pencil but subsequently added ink and colour to some of her work.

Around 300 of Lentaigne's drawings have been preserved at the East Grinstead Museum, as the Mollie Lentaigne Collection. After the surviving Guinea Pig Club members used social media to search for Lentaigne and found her living in Zimbabwe, she returned to East Grinstead in 2013 to be reunited with her work."

She was 93 at the time, and is still alive at the age of 103.
In my attempt to read a history of the 1918 influenza pandemic informed by modern knowledge of viruses, I have so far managed to read a hagiography of Great White Male scientists associated with Johns Hopkins plus some chapters on the 1918 pandemic (Barry), and an account of the search for the causes of the 1918 pandemic plus one chapter on its history and a long digression into the political fallout of the swine flu vaccination in America in 1976 (Kolata). Surely the book I thought I was going to read exists and I just haven't found it yet... right?

Kolata's book is a delightful antidote to Barry's endless chapters on Welch, whose sole contribution to the pandemic was a single field trip followed by getting it himself, and Lewis, who wasn't involved at all; she mentions them both to say that they were noted and notable, but did not contribute to knowledge of the causes of the pandemic. Bye-bye, Welch and Lewis!

Kolata has a fascinating account of efforts at the time of the pandemic and shortly afterward to figure out its causes. Very gross and often dubiously ethical efforts, involving spraying gunk from sick/recovered people's noses and mouths into healthy people's noses and mouths, in varying degrees of filtration, to see if it would get them sick.

An early American experiment with prisoners failed to get any of them sick. Barry details this but annoyingly does not explain why. Apparently it's still somewhat mysterious, but according to Kolata, the most likely explanation was that the prisoners had all been asymptomatically infected and so had immunity, or that the secretions from flu victims were collected too late in the disease process, when the virus itself was mostly gone and the people were dying of the cytokine storm reaction to it, and so were no longer infectious. Or a combination of both.

In 1918 - 1919 three Japanese doctors performed an experiment which Barry doesn't mention at all, choosing instead to spend chapters detailing the efforts of Johns Hopkins scientists which went nowhere. The Japanese doctors experimented on healthy subjects, including volunteer doctors and nurses. They filtered sputum and blood from flu victims to remove all bacteria, then introduced the filtrate to their subjects in multiple ways. They did the same with bacteria extracted from flu victims. The results were exactly what you'd expect if the cause was a virus: the no-bacteria filtrates gave all the subjects influenza, and the bacteria-only didn't. Subjects who'd already had the flu didn't get sick regardless.

These results were so convincing that... the world at large decided they were too neat to be believed. 100% of the subjects got infected from hypothetical viruses, and 0% from bacteria. No way!

[world's biggest facepalm.]

Later experiments determined that ferrets can get influenza. The notes on how difficult ferrets were to work with are pretty hilarious. Apparently lots of scientists got bitten and possibly got ferrets down their trousers before they threw up their hands and anesthetized the ferrets before trying to stick things in their mouths and up their noses. This work led to a series of experiments looking at connections between flus that can infect humans, pigs, ferrets, and finally mice. (Most animals don't get or transmit human influenzas.) In 1934 several groups of scientists working independently found that swine flu and human flu viruses are not identical, but are related; antibodies from one can provide partial immunity to the other.

Meanwhile, the 1918 influenza seemed to have vanished. But there had been a swine flu outbreak at the same time, and that was still around. And survivors of the 1918 pandemic all had antibodies to the current swine flu virus, while people born after the pandemic did not. So, was the current swine flu virus in fact the 1918 pandemic virus, mutated to no longer infect humans and living on in pigs?

Kolata then has a very charming chapter about a Swedish scientist, Johan Hultin (whose wife Gunvor was also a scientist, in radiation biology), who worked on influenza in the US and got interested in finding original samples of the 1918 virus. They had earlier traveled to Fairbanks, Alaska, and went around with a paleontologist digging up mammoth tusks. It occurred to Hultin that as Alaska has permafrost, some bodies of flu victims might still be preserved. In 1951 he took an expedition to Brevig, where 72 of 80 people died of influenza in November 1918, and were buried there.

In a surprising and pleasingly ethical manner, Hultin visited the current town and survivors/descendents, told them what he wanted to do and why, and asked their permission to exhume some bodies and take samples. They agreed. He then discovered how hard it is to dig in ground that's frozen solid, and ended up having to melt down to the bodies. But he did it, and took samples.

It did not occur to him that he might be unleashing the virus on the world all over again. They did take precautions, but it was 1951 and they were wildly inadequate. Luckily, there were no consequences. But alas! Upon his return to his lab, he totally failed at extracting any virus from the samples. He tried infecting animals. He tried growing it in eggs. Nothing.

Kolata then jumps ahead to 1976, when an American private at boot camp died of swine flu. At that point scientists could isolate viruses and quickly found that 1) yes, it was swine flu, 2) it seemed closely related to the one that was theorized to have caused the 1918 pandemic.

Kolata then spends a long, rather dry chapter dissecting the political ramifications of the US decision to attempt to rush-vaccine the entire country to prevent a pandemic. This turned out to be unnecessary and ended up very expensive and embarrassing, as a number of people sued after they vaccinated and got sick. Kolata's view is that most if not all of the post-vaccination illnesses and deaths were coincidental and not caused by the virus. Nevertheless, the US government had to pay out a lot of money and also looked bad.

Everyone involved mostly felt that they'd been too quick to rush to a vaccination and should have listened to the people who thought the swine flu was no big deal. Reading this chapter now, my sympathies are entirely with the scientists who thought they needed to move fast to prevent another pandemic. They were wrong... but they easily could have been right.

Flu: The Story Of The Great Influenza Pandemic of 1918 and the Search for the Virus that Caused It

Now THIS is what I read the book for. (Mostly. It also features Barry writing It was only influenza at least thirty times in three chapters. Give it a rest, Barry. Go polish your portrait of William Welch in your bunk.)

In these chapters Barry dissects the absolutely terrible response of the US government to the pandemic, a combination of deliberate inaction, counterproductive action, and false propaganda unequaled until the current pandemic response, which is very strongly resembles.

From neither the White House nor another senior administration post would there come any leadership, any attempt to set priorities, any attempt to deliver resources.

Read more... )

The more things change, the more they stay the same.

The Great Influenza: The Story of the Deadliest Pandemic in History

In which Barry finally gets to the actual pandemic!

He starts with the first wave, which was spread largely by WWI and which had high mortality in some limited outbreaks, but which mostly got taken seriously because of its prevalence and effect on WWI - soldiers were too sick to fight. However, the mortality was often low and the illness itself not serious for any given individual; it had a big effect on the war, then apparently vanished.

At this point it got called "The Spanish flu" because Spain was the only country that was not doing wartime censorship, and so was writing about it honestly!

And then the second wave hit.

While reading Kolata's book, I felt that her account of the beginning of the pandemic felt rushed and sudden. Now that I've read Barry's account of when the second wave hit, I realize that it's not because of her writing because his account, which is written at far greater length and in a very different style, gave the same impression. I think that in fact, accounts of the pandemic inevitably reflect the accurate experience of the pandemic, which is that at a certain point everything suddenly blows up and is overwhelming and all over the place.

Barry's account of this is vivid and horrifying, both of the symptoms, the avalanche of death, the total overwhelm of society, and the completely useless lack of action by anyone who was capable of taking large action. Due to the war, the government was primarily invested in telling everyone everything was fine, with the result that parades were held, people attended and then dropped dead, soldiers were blithely shipped around while infected, etc. Sound familiar?

The second wave (a mutation of the original virus) had a lot of symptoms that were not normal influenza, primarily ebola-like bleeding. He hasn't yet explained what exactly caused that. It also caused widespread, severe cyanosis, so people's skin literally turned dark blue or black. This made some people believe it was literally the Black Plague. (Very understandable IMO: people bleed severely, cough, and turn black, which pneumonic plague also does.)

Barry says that cytosine storms account for the virus being primarily deadly in the 20-40 age range, as that group has the strongest immune response. He hasn't yet explained why that happened with this influenza specifically, rather than for normal influenzas or other viruses for that matter. Pregnant women had the single highest mortality rate - up to 70%. I don't understand that either - they're normally immunocompromised, right?

Barry has a detailed account of the scientists and doctors trying to figure out causes, treatments, and a vaccine. They're currently mostly going down a rabbit hole of pinning the blame on bacillus influenzae, a gram-negative bacteria which was present in most of the people infected. I guess it was a very common opportunistic infection, as we already know the actual culprit was a virus.

Barry finally finds one woman worthy of focus, the bacteriologist Anna Williams... whom he describes as "a lonely, unmarried woman." SIGH. Meanwhile the men get reams and reams of loving description even if they are literally not doing anything.

It turns out that William Welch's sole personal involvement in the pandemic was visiting one outbreak, and being visibly disturbed and saying he thought it was a new disease. He then got it himself, recovered, and had literally nothing to do with it again ever! This makes Barry's decision to start the book with a loooooooooong chapter about him seem even more inexplicable. He mentored a number of people who ended up actually doing important stuff during the pandemic, but everyone has mentors.

The Great Influenza: The Story of the Deadliest Pandemic in History



[personal profile] oyceter has a good rundown of virus details.
If anyone's wondering why the hell I'm reading about historical pandemics, apart from curiosity, the answer is this: they are proof that this too shall pass.

This book could not be more different from Barry's. Reading them concurrently was a good choice. Kolata's focus is twofold: why the 1918 flu pandemic was so much less written about than pretty much every other pandemic before and since, and the scientific mystery of what it was and how both historical and modern researchers tried to unravel that.

So far, at least, Barry had not touched on the first subject at all and is interested in modern research only insofar as it illuminates what was done by the Great White Men during the pandemic. Conversely, Kolata only mentions the greatness of historical white men to place them in context, noting that Welch was very well-regarded at the time to explain why he was dispatched as an old man to investigate the flu outbreak and why the fact that it alarmed even him was notable.

Kolata starts with her history as a student of microbiology to note that the influenza pandemic was barely touched upon compared to other pandemics she studied, and that she got curious as to why such a huge event seemed comparatively lost to history. Then she plunges straight in to an incredibly whirlwind account of it, which conveys its impact without really explaining the how and why. (Notable to me: Tucson, AZ mandated the wearing of masks by everyone.)

Chapter two is not actually a history of all disease THANK GOD, but a brief history of the chronicling of historical plagues, to point out that there was a noticeable lack of that for the 1918 epidemic. She goes into some detail about how little the 1918 epidemic was chronicled at the time and afterward in relation to its immense impact - the doctors who were central in dealing with it barely mention it in their memoirs, a 500-page of William Welch gives it two paragraphs, etc. She surmises that the reason for this is that it was overshadowed by/subsumed into the trauma of WWI, did not leave a large number of disabled survivors, and vanished after running its course, making it both inviting and easy to not dwell on.

Kolata leaves me wanting historical detail and context, which Barry provides. Barry leaves me wanting modern context and perspective, which Kolata provides.

Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It

"The Swarm," about the probable origin of the pandemic (Kansas) and the biology and mechanics of viruses, and parts of "The Tinderbox," about America's entry into WWI and the propaganda machine and censorship to support that, made me realize why this is a well-regarded book. The section on viruses is very clear, and a lot of the history is compelling. I understand that there are competing theories for the origin of the pandemic but he lays out a convincing case for Kansas.

I'm baffled by why Barry chose instead to start the book with the ponderous chapter on William Welch given that all we really need to know was that Johns Hopkins was important... no, wait, I totally understand why Barry chose to do that:

At the top sat Welch, fully the impresario, capable of changing the lives of those upon whom his glance lingered, capable as well of directing great sums of money to an institution with a nod. Only he held such power in American science, and no one else has held such power since.

Get a room, Barry.

He continues to go on and on about the amazing! greatness! of the amazing Great White Men. It's particularly noticeable in his section on nursing, where he clearly states the problems nurses faced due to sexist doctors and the importance of the almost entire female nurses... but does not give any nurses the amazing! great! individual treatment. The most any of them get is one paragraph explaining why they were important and calling them "intelligent." As opposed to the bazillion quotes and analysis and praise the men get.

Reading the facts presented, I'm less struck by how wow! extraordinary! the individual dudes were, and more by the staggering obstinacy and stupidity of the government, medical establishment, military, and all large powerful organizations in general (yes Barry, Johns Hopkins excepted). Literally every time anyone tries to do anything for public health, there's enormous opposition. The more things change...

The section on censorship, propaganda, and racism in WWI is alarming given what's going on in America now; the more things change...

The Great Influenza: The Story of the Deadliest Pandemic in History

He was every bit a warrior, and he hunted death.

Barry has a very distinctive, bombastic style. The introduction in particular feels like it should be scored with Beethoven's Ninth. It tells a compelling story, of the beginning of the pandemic, and asserts, bolstered by Goethe quotes because why not, that the pandemic transformed medicine and science worldwide but especially in America.

Barry then plunges into a summary of the entire history of science and medicine in the western world, especially post-colonial America, before plunging even more enthusiastically into an account of the founding of Johns Hopkins and one of its founders, William Welch, on whom Barry seems to have a massive crush.

These hundreds of the world's leading scientists had measured him as coldly and objectively as they measured everything and found him worthy.

His legacy was not objectively measurable
[I guess except to those scientists] but it was nonetheless real. It lay in his ability to stir other men's souls.

Barry then goes on and on and on about how charming Welch was. It doesn't really come across, unfortunately. His best friend apparently fall unrequitedly in love with him, they had a huge fight, and Welch never got intimate or even emotionally close to anyone ever again.

Also, he studied in Germany at a time when American medical schools were basically totally useless, unregulated diploma mills. He returned to teach at the newly founded Johns Hopkins, which was the first academically rigorous American medical school, where he charmed everyone in his path - again, this is told not shown. He sure charmed Barry, though!

Barry is clearly a member of the "Great White Men" school of historians.

Takeaways: Johns Hopkins transformed American medicine from completely backward to comparable with Europe. Germ theory at this time was beginning to take precedence over the competing "miasma" and "filth" theories. (Filth theory was so close! Disease really was spread by sewage, rats, fleas, etc. It was just caused by bacteria or viruses carried in filth, not directly by the filth itself.)

Also, Welch was the best. THE BEST.

The Great Influenza: The Story of the Deadliest Pandemic in History

rachelmanija: (Books: old)
( Apr. 12th, 2020 12:25 pm)
I fully expect that only me and Oyce actually want to do this, but just in case anyone else is interested and wants to read along, we're doing an informal pandemic book club.

We're going to start with The Great Influenza: The Story of the Deadliest Pandemic in History by John M. Barry. It's fairly long/dense, so we'll read and post in sections. After that, we'll read some other pandemic books (mentioned in the first link).

No strict timeline, no actual rules. Basically we're just interested in learning more about pandemics. If you want to read other pandemic books, go for it and please link me. If you want to rec other pandemic books, please do!

A thoughtful, well-researched, and compassionate look at care, both medical and otherwise, for living and dying in old age.

Gawande looks at the history and current state of his subject in America, with some forays into India, which is where his family is from. Unlike most people who pontificate about the good old days and how things are done elsewhere, when he writes about that, he's speaking from both actual history and personal/family experience.

The easy answer to "why is old age horrible in America nowadays" is that old people used to be cared for at home by their families, which was the right way to do it, but nowadays the family is broken/young people are selfish/capitalism is bad, so they're pushed into horrible and unaffordable nursing homes. Well... the part about horrible and unaffordable nursing homes is true. But the rest is more complicated.

Historically, not all old people had families, or families who could care for them; the ones who didn't died in the streets, or in horrifying poorhouses or debtors' prisons. So "the family can and should do it" has never been a complete answer.

Gawande presents an example from his own family of what in some regards is the ideal state of at-home elder care. His great-grandfather lived to be 103, was helped with the care he needed but nobody stopped him from doing what he wanted, and died on a business trip! But, since Gawande is looking at real people rather than imaginary ones, he can also see the problems with this: the old man was still bossing his family around way past the point when they wanted to be able to make their own decisions, and there were a bunch of family problems due to that.

When old people are cared for at home by their family, it often means that the younger people don't get to live their own lives. In Gawande's case, this had the biggest effect on sons who wanted independence, but historically it mostly means that women (typically the youngest daughter) spend their entire lives devoted to a parent. The parents don't necessarily want to live with their kids, either.

He's not saying that all generations living in the same home in perpetuity is always bad, just that it's not necessarily the ideal or best option.

Gawande then explores how assisted living and nursing homes are frequently horrible and treat old people like prisoners, then looks at a number of case studies of homes for old people that are not like that, from the original assisted living that was the ideal of what that should mean, to a nursing home that moved in four cats, two dogs, and one hundred parakeets to cheer things up, to an apartment building with a very devoted manager.

He makes a strong and moving case for the needs of the elderly for both care and independence/choice, including choices that are risky. People shouldn't lose their rights just because they're old.

He also uncovered some fascinating research on how people prioritize their lives. Young people tend to invest in the future, doing things that will produce rewards later, like going to college, working at jobs they don't like to save money, etc. They also tend to look outward: traveling, making new friends, etc. Old people tend to focus on the present: spending time with family and existing friends rather than making new ones, enjoying daily activities rather than special occasion ones.

This is true across cultures, and is also pretty obvious. But Gawande looks at research that digs into why. Conventional wisdom is that old people act that way because their accumulated life experience teaches them what's really important. But it turns out that in fact, it has to do with the perception of how much time you have. When young people get life-threatening illnesses, they start behaving and prioritizing like old people. When you ask old people to imagine what they'd do if their life was extended by twenty years past what they really have, they start prioritizing like young people.

When you think your time is limited, you focus on the present, current loved ones, and daily pleasures. When you think you've got plenty of time left, you focus on the present, meeting new people, and doing new things. Old people aren't wiser in that regard, they're just making choices that make sense under their circumstances - the same as young people are doing.

Note that this isn't all people all the time, obviously. It's just about overall social trends: young people as a group are more likely to behave in X ways, not "all young people are future-focused."

The book also explores end of life care, but I knew more about that going in, and so was more struck by the parts about living in old age rather than dying in it.

Absolutely perfect cover. If you can't see it well, it's a blade of grass (embossed, on the physical book) casting a shadow.

Being Mortal: Medicine and What Matters in the End

The Curse of Nonfiction strikes again: fascinating topic, dry book.

An account of pioneering burn surgeon Archibald McIndoe and The Guinea Pig Club, a group of badly burned WWII airmen who he treated in a small hospital in England. McIndoe not only revolutionized techniques for treating and reconstructing burn injuries, he also helped the men integrate into the community. (Link goes to Wikipedia; good article, no gruesome photos.) I got interested in this after reading Richard Hilary's memoir, The Last Enemy.

It’s a really interesting story, but the book was a bit of a slog that periodically came to life in the handful of first-person accounts by the airmen themselves. It also benefited from both photos (not gruesome IMO – they’re of the men, not of the burns themselves - though some are startling/unsettling as they show some stages of reconstruction. Read more... )). Also cartoons by a member of the Guinea Pig Club.

I did appreciate the historical background. For instance, it explains that one reason McIndoe's techniques were revolutionary was that previous to WWII, anyone burned as badly as many of these men would have died within hours or days, and so reconstructive surgery for those sorts of injuries was a moot point. This was the period when doctors were figuring out how to treat shock, which meant that all of a sudden, people were surviving with wounds that previously would have killed them. And then doctors had to figure out what to do to help them then. (Incidentally, the issue of what to do with people with previously non-survivable injuries is still ongoing, and there have been conceptual breakthroughs in how to treat shock/blood loss just in the last ten years - also due to war. It's the quintessential mixed blessing.)

There’s also a very informative explanation of why so many men got burned the way they did (placement of the fuel tank) and why that was such a difficult issue to solve, as among other problems a lot of the possible solutions would have made the planes heavier and so slower and less agile, which then would make them more likely to be hit in the first place.

However, I was primarily interested in the experience of the airmen and those parts were good, but the rest of the book was pretty textbook-y. I also would have liked to know more about what their lives were like after they left the hospital.



I see now that another member of the Guinea Pig Club wrote a memoir. I’m thinking that’s what I actually want to read.

The memoir of a neurosurgeon, focusing on how dangerous it is for patients, how it's often a complete gamble whether surgery will cure them or kill them (or paralyze them, or leave them in a permanent coma, etc), and how much that gets to the author.

If a book which is largely about the doctor's feelings as opposed to those of his patients, when the catastrophe happened to them rather than to him, annoys you on principle, don't read this. Personally, I liked knowing that there is at least one more doctor in the world who cares what happens to his patients, even if the caring is composed in equal parts of compassion, professional pride, and fear of being publicly shamed.

As that suggests, it's a memoir dedicated to saying how he really feels, whether that's elevated or petty. He spends quite a bit of time on justifiable raging over his hospital's incredibly terrible computer system, which keeps locking up the password so no one can see the scans they need to operate (hilariously, at one point some equally angry person sets the password to fuckyou47 (and then no one can remember if it's 47, 46, 45...), the lack of beds that mean that patients are deprived of food and water all day pending surgery and then the surgery gets canceled, and all the other myriad ways in which health care in England now sucks. (It still sounds about a million times better than health care in America.)

He talks frankly about his mistakes as a surgeon, some of which killed people. This is really a taboo topic, and my hat is off to him for going there.

There's also a lot of fascinating anecdotes about individual patients, and some beautiful writing about surgery, the physical structure of the brain, and the constant paradox of how that one squishy organ is the source of everything that makes us human and able to do things like write books, all of which is a source of wonder to him and one which he conveys very well.

It's definitely worth reading if the subject interests you, but it doesn't quite rise to the level of medical writing that I'd recommend whether the subject interests you or not. (My nominees for the latter are Atul Gawande, Oliver Sacks, and James Herriot.)

Do No Harm: Stories of Life, Death, and Brain Surgery
By the author of National Velvet, which if you’ve never read it is a quite unusual book with a distinctive prose style and atmosphere that I find quite lovely, especially at the beginning. It doesn’t read at all like your typical girls-and-horses book, though it is that as well.

A Diary Without Dates is Bagnold’s memoir of nursing soldiers during WWI. It’s also written in an unusual, distinctive style, with an unusual, distinctive atmosphere, both gritty and impressionistic. She captures fleeting moments of beauty or horror or unexpected humor, and the sense of how fleeting those moments are, in a way that reminds me a bit of Banana Yoshimoto, of all the unlikely comparisons. I’ve read a number of memoirs by WWI nurses, and this is by far the most interesting on the level of literature. It’s not so much a diary as a record of memorable moments, thoughts, and feelings.

Though it’s not about therapy, it’s one of the books that comes closest to capturing what doing therapy feels like for me. Bagnold delicately and precisely observes the odd mixture of intimacy and distance between nurse and patient, in an institutional setting with inhuman rules against which intensely human dramas are played out, and how you can share a person’s greatest agony one hour, and then walk outside and be moved by the beauty of a flower or annoyed by the next nurse over, and have all those moments be equally real and deeply felt, though some seem trivial and some profound. But to Bagnold, they're all profound because they're all real moments of life, and life itself is profound. A few other works that have that feeling to me are the Tove Janssen's The Summer Book and Anita Desai's The Peacock Garden, and the WWII movie Hope and Glory.

Though it’s not particularly an expose, Bagnold writes rather unflatteringly about some of her bosses and some of the rules at the hospital where she worked. As a result, she was fired when the book came out. So she went to London and became an ambulance driver. I think she must have been quite an interesting person, and reading her diary, I wished that I could have known her. I think we might have had a lot in common and a lot to talk about.

Note: Contains some of-the-period racism and other isms. Not a lot and it’s typical of books written in that period by white people (as opposed to being more racist than usual), but there’s at least one instance though I have now forgotten the details.

Dr. Lisa Sanders is the doctor who inspired the TV show House. She is apparently a genius diagnostician and if her waiting list was not three years long, I would have already seen her. Her book is marketed as tales of medical mysteries and their diagnoses, complete with the doctor’s process of diagnosing, which is why I bought it.

Approximately 20% of the book consists of that. The other 80% is her opinion that the physical examination of the patient (as opposed to mechanical scans) has a long history, is very important, is underused and poorly taught, and needs to be taught better and done more. She’s probably right but it was incredibly repetitive. She could have summed up her thoughts on that in one or two chapters, leaving the rest of the book for the stories which is undoubtedly why everyone bought it. Annoyingly not what it says on the tin.

Every Patient Tells a Story: Medical Mysteries and the Art of Diagnosis

Any recs for books that are actually about diagnosis? (Medical, not psychological; I'm good on the psych front.)

Also, any recs for a book on antibiotics that is 1) about their current use, not their history (I'm familiar with their history), 2) comprehensible to a layperson?

I am particularly interested in learning more about how, after spending my entire life being told that antibiotics have very limited and specific uses and do not cure most things (due to doctors trying to cut down on inappropriate usage) I have recently discovered that, in fact, they have an extremely wide range of uses and "condition responds to antibiotics and, as far as we can tell, to nothing else" is nowhere near as diagnostically useful as I had assumed in narrowing down what that condition might be. For instance, d-cycloserine, an antibiotic normally used to treat tuberculosis, has cognitive effects which may make it useful in the treatment of PTSD.
This was one of my class textbooks and is written for psychology students, but it’s easily accessible to the layperson. If you’re a writer and are thinking about writing a character who’s a therapist or psychiatrist, this book will give you all you need to know about diagnosing mental illness in America. (It’s based on the diagnoses in the DSM-IV.)

In easy-to-follow logic and clear prose, Morrison lays out the steps for diagnosing a patient with a mental illness, or concluding that they’re not mentally ill. He has his own hobbyhorses, most notably his fondness for somatoform disorders, but other than that, the way he thinks is the standard way that diagnosticians think. My caveat is that he doesn’t get into cultural/social factors at all. Otherwise, this is a very good basic text.

Ing Hay was a doctor of traditional Chinese medicine (herbal, pulsology) who practiced in a small, primarily white Oregon town from about 1900 to 1948. He got extremely impressive results, by all accounts, and quickly expanded his practice from the Chinese community to everyone in the vicinity, and eventually became so sought after that people starting traveling to see him. He even sometimes treated patients long-distance, via letters and packages of medicine!

(Sherwood: his predecessor, also a Chinese herbal doctor, was “Doc Lee.”)

This slim book gives a reasonable précis of his story, and that of his business partner, Lung On. The latter sounds like quite a character as well. Unlike Ing Hay, he spoke fluent English, dressed in western clothes, and apparently had not-particularly-discreet affairs with white women. Because of their barbaric attire and so forth, Lung On and a friend of his with similar predilictions jokingly called themselves “Oriental barbarians.”

Though the material is fascinating, the book suffers from a dry writing style and a lack of background and investigation. It’s very much “just the facts,” without much follow-up into their background and context. A reader unfamiliar with the period would need an explanation of the Chinese Exclusion Act (alluded to but not detailed within); a reader who already knows that sort of basic context, like myself, would have appreciated some explanation of things like, for instance, where Ing Hay was getting his Chinese herbs. (From other Chinese herbalists in San Francisco, who imported them from China. But I had to look online to find that out.)

Interesting history, so-so account.

China Doctor of John Day, Oregon
A fascinating, easily readable history of cancer, how people conceived of it, how they tried to cure it, and how all that changed society and science. Mukherjee is an oncologist, and salts the text with anecdotes about his own patients. (Those were great and I would have liked more of them.)

If you like pop science at all, this is a great example of it: educational, clearly written, both explaining things you always wondered about (why is there so much cancer nowadays?) and delving into issues it never occurred to you wonder about (how did we get from a time when the New York Times refused to print the words “breast” and “cancer” to marathons for a cure?) Mukherjee takes us from bone tumors found in ancient mummies, to the Persian queen Atossa who had a slave perform a mastectomy on her, to the genesis of “wars on diseases” and campaigning for funds and cures, to the beginnings of chemotherapy, to cutting edge genetic research. He brings all the personalities of the scientists, the politicians, the patients, and the (evil! evil!) tobacco company executives to vivid life.

I probably don’t need to mention that this book can be gross, upsetting, and disturbing, given the subject matter. (The section on radical mastectomies was especially nightmarish.) But if you can either deal with that or skim a bit, I highly recommend this.

Every Patient Tells a Story: Medical Mysteries and the Art of Diagnosis, by Lisa Sanders, a doctor who's the consultant for House (I am sure she is not to blame for its inaccuracies, though), is a solid, readable book about... well, exactly what it says on the tin, but with the most attention paid to the physical exam, which according to Sanders is a dying art in America. I still think the best book on the subject is Atul Gawande's Complications: A Surgeon's Notes on an Imperfect Science, which reaches the heights of fine literature, but Sanders's book is informative and worth reading if you're interested in the subject.

Every Patient Tells a Story: Medical Mysteries and the Art of Diagnosis

Arthur E. Hertzler's The Horse and Buggy Doctor (Bison Book) is more of general interest, assuming that medical details don't make you turn green and then faint. He wrote it in 1938, looking back on his long career as an American doctor, and the first chapter looks even farther back, to medicine as it was practiced in his boyhood (the 1880s).

This is well worth reading for two reasons: the content is fascinating and eye-opening, even if you already have a decent background in medical history, and Hertzler's style is unique, oddball, literate, grumpy, and vivid. He has a way with deliberately stilted and roundabout phrasing that cracked me up.

To return to the female complaints. One may divide them into two general classes: the female complaints and the male complaints. The former include those due to maladjustments between the biologic and the ethical. Male complaints, on the other hand, are those in which man is the aggravating factor or, maybe, the regressive factor. These are subtle things which only doctors can hope to understand.

...

The more intimate relations between doctor and patient have never before been discussed in print, but I am going to come nearer to doing so than has yet been done. Only an old doctor who has lived with people knows this relationship…. The more nearly the doctor's experience of life has paralleled the patient's before him, the better he is able to understand that patient. The tragedies of literature are silly things; they must be made simple and obvious or else they will not be understood. Shakespeare wrote tragedies out of his imagination, not from experience. They are foolish, because he had not seen life in the raw. Tragedies cannot be written. They are inarticulate.

I wish every parent considering not vaccinating their child was obliged to read the first chapter, in which he relates how common it was for children to die of now-preventable diseases; one family had nine of ten children die of diptheria. He proceeds to explain exactly what death by diptheria looks like. I already knew this, but his description brings it to horrifying life.

Not all of the book is that intense, and much of it is quite funny. If you can bear reading about death and gross procedures, I recommend it.

An Asian-American surgeon’s memoir on the theme of the difficulty doctors, patients, and society have in coming to grips with death, and how this results in a lot of unnecessarily painful and unpleasant deaths for patients, trauma for their loved ones, and psychological unhealthiness in doctors.

The parts which I found most interesting were when she looked at attempts made to correct this, and tried to analyze why, so far, they have tended to be spectacularly ineffective. (One all-out effort, sustained for two years, produced no measurable results.) There’s no one reason for this, apparently, but contributing factors include doctors feeling that they’re already too busy and not seeing classes in relating to patients as a priority, no one wanting to think about death (patients included), the feeling that death is an admission of failure causing even less desire to think about it, and fear of lawsuits.

I read this book out of interest in the subject matter; it’s reasonably well-written but not so superbly so that I’d recommend it whether you’re interested in the topic or not. If you do have a prior interest or if you haven’t already read a lot of memoirs by doctors, this is a perfectly good book, meticulously researched, thoughtful, and honest. I was a little underwhelmed, but I’ve already read quite a few similar books and at this point it would take something pretty stellar to stand out from the pack. Atul Gawande is the gold standard as far as I’m concerned.
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